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. 2019 Jul 30;93(16):e00313-19. doi: 10.1128/JVI.00313-19

FIG 4.

FIG 4

RNase L activation does not impair ZIKV replication. Supernatants were collected from infected cells at the indicated times postinfection and titrated on Vero cells for determination of the viral titer in PFU/ml over time postinfection. (A) A549 cells were infected with ZIKV PR at MOIs of 0.01 and 0.1. Two different RNase L KO clones were assessed, and representative titers from one clone are shown. (B) HT1080 cells infected with ZIKV PR at an MOI of 0.1. (C) A549 cells infected with DENV at MOIs of 0.01 and 0.1. (D) A549 cells infected with SINV at an MOI of 0.1. Statistical significance was determined by two-way ANOVA; the means of three replicates ± the SD are shown (**, P < 0.01; ***, P < 0.001; ****, P < 0.0001). The data shown are representative of two to three experiments.