Table 3.
Demographics and clinical characteristics.
| MCI | AD | P-value | Total | |||
|---|---|---|---|---|---|---|
| Training set | Age | 73.9 ± 6.7 | 72.5 ± 7.3 | 73.9 ± 7.9 | 3.22·10[‐]−4 | 73.2 ± 7.0 |
| Years of education | 16.4 ± 2.7 | 15.9 ± 2.8 | 15.2 ± 2.9 | 1.09·10[‐]−6 | 15.9 ± 2.8 | |
| eTIV (cm3) | 1510± 180 | 1540 ± 160 | 1530 ± 160 | 4.20·10[‐]−3 | 1530 ± 160 | |
| MMSE | 29.1 ± 1.2 | 27.6 ± 1.8 | 23.2 ± 2.0 | 2.2·10[‐]−16 | 27.3 ± 2.6 | |
| Sex (% of females) | 52% | 42% | 48% | 1.43·10[‐]−3 | 46% | |
| APOE4-carrier | 34% | 49%* | 66% | 2.2·10[‐]−16 | 49% | |
| Test set | Age | 56 ± 17 | 70.6 ± 7.7 | 73.7 ± 8.1 | 2.2·10[‐]−16 | 62 ± 16 |
| Years of education | 10.8 ± 4.8 | 9.0 ± 4.5 | 8.7 ± 4.5 | 2.2·10[‐]−16 | 10.2 ± 4.8 | |
| eTIV (cm3) | 1450 ± 160 | 1460 ± 170 | 1470 ± 170 | 0.157 | 1460 ± 160 | |
| MMSE | 28.7 ± 1.4 | 26.5 ± 2.4 | 21.0 ± 4.7 | 2.2·10[‐]−16 | 26.6 ± 3.9 | |
| Sex (% of females) | 61% | 49% | 63% | 1.50·10[‐]−5 | 58% | |
| APOE4-carrier | 21% | 43% | 49% | 2.2·10[‐]−16 | 43% | |
Data are expressed as mean values ± standard deviations. Acronyms: eTIV: estimated total intracranial volume; MMSE: Mini Mental State Examination; APOE4: apolipoprotein E ε4; CN: cognitively normal; MCI: mild cognitive impairment; AD: Alzheimer's disease. P-values were calculated via chi square test for dichotomic variables and via ANOVA for non-dichotomic variables. Values of training set denoted with * are not significantly different from their corresponding values derived from the test subjects (p-value >0.05).