Table 5.

Measurements of area under curve (AUC), sensitivity (Sens), specificity (Spec) and balanced accuracy (BalAcc) at a specific threshold (k_T) for the staging obtained with EBM and DEBM methods on training and test data sets not containing missing values.

	EBM					DEBM					p-value
	kT	Sens	Spec	BalAcc	AUC	kT	Sens	Spec	BalAcc	AUC
Training set
AD vs CN	8	0.98	0.95	0.97	0.97	3	0.86	0.99	0.92	0.95	3.10 10−2
AD vs MCI	8	0.70	0.95	0.83	0.83	7	0.66	0.76	0.71	0.76	0.104
MCI vs CN	5	0.89	0.51	0.70	0.72	3	0.86	0.58	0.72	0.73	1.99 10−8
Test set
AD vs CN	4	0.88	0.94	0.91	0.95	3	0.91	0.91	0.91	0.94	0.332
AD vs MCI	4	0.57	0.94	0.76	0.80	5	0.63	0.87	0.75	0.79	1.65 10−2
MCI vs CN	4	0.88	0.43	0.66	0.66	3	0.91	0.52	0.71	0.70	0.296

P-values of Delong test performed to compare AUCs of EBM and DEBM methods are reported in the last column. In DEBM and EBM AUCs of the training set were not significantly different to their corresponding AUCs in the test set (p-values of DeLong test always >0.05).