Skip to main content
. 2019 Jul 27;21(9):863–871. doi: 10.1016/j.neo.2019.06.006

Figure 4.

Figure 4

Effect of repeated AsiDNA treatment in MDA-MB-231 cell-derived xenografts. Growth of MDA-MD-231 cell-derived xenografted tumors mock treated (black lines) or treated (gray lines) with three cycles of AsiDNA (gray rectangles) with different schedules: (A) 5 consecutive days of injections (5 mg/injection) followed by 17 days of rest (vehicle, n = 6; AsiDNA, n = 8) or (B) 3 consecutive days (15 mg/injection) followed by 12 days of rest (vehicle, n = 5; AsiDNA, n = 10). Data are represented as mean ± SEM. (C, D) Transcriptomic analysis of three tumors mock-treated (NT) or treated with AsiDNA (AsiDNA3C). Three mice from each group treated with protocol B were sacrificed at day 38 and analyzed: (C) hierarchical clustering of regulated genes and heatmap analysis. (D) Venn diagram representation of genes differentially expressed and genes interacting with DNA-PK. Overrepresentation of DNA-PK was calculated by Student t test.