Table 2.
Regional cerebral oxygen saturation (rScO2) values for cardiac surgery patients with and without postoperative cognitive dysfunction (POCD) at discharge and at 3 months—entire Perfusion Pressure Cerebral Infarct (PPCI) trial population. Median with (inter-quartile range) and tested with Mann–Whitney U-test. Differences calculated as independent samples Hodges-Lehmann median difference estimates with 95% confidence intervals (95% CI). CDL, cerebral desaturation load (area under these thresholds); CPB, cardiopulmonary bypass
|
Postoperative cognitive dysfunction at discharge |
||||
|
No (n=109) |
Yes (n=44) |
Difference (95% CI) |
P-value |
|
| Preoperative rScO2 | 66.5 (61.0; 71.5) | 64.5 (60.0; 71.0) | 2.0 (−1.0; 4.5) | 0.21 |
| Mean rScO2 during CPB | 67.3 (61.1; 73.3) | 65.3 (61.0; 71.1) | 1.2 (−2.0; 4.3) | 0.47 |
| Mean rScO2 during surgery | 69.0 (64.5; 73.4) | 69.0 (61.4; 71.9) | 1.6 (−1.2; 4.2) | 0.27 |
| Time below preoperative rScO2 (min) | 54.1 (18.2; 122.5) | 75.6 (10.6; 137.1) | 3.6 (−12.8; 29.3) | 0.68 |
| Time below a 10% decrease from preoperative rScO2 (min) | 3.8 (0.2; 28.2) | 5.31 (0.1; 46.4) | 0.0 (−3.1; 1.5) | 0.88 |
| Time below a 20% decrease from preoperative rScO2 (min) | 0.0 (0.0; 0.7) | 0.0 (0.0; 1.1) | 0.0 (0.0; 0.0) | 0.73 |
| CDL preoperative (% × min) | 223.8 (39.4; 493.0) | 267.8 (26.1; 768.1) | 5.3 (−57.0; 134.5) | 0.80 |
| CDL10 (% × min) | 5.3 (0.0; 73.0) | 9.5 (0.0; 105.9) | 0.0 (−4.5; 2.0) | 0.98 |
| CDL20 (% × min) | 0.0 (0.0; 1.5) | 0.0 (0.0; 3.3) | 0.0 (0.0; 0.0) | 0.95 |
| Minimum rScO2 value | 55.0 (49.3; 61.0) | 53.3 (47.1; 58.5) | 2.5 (−0.5; 5.5) | 0.11 |
| Maximum rScO2 value |
82.5 (76.5; 87.8) |
81.8 (77.0; 85.5) |
0.5 (−2.5; 3.5) |
0.68 |
|
Postoperative cognitive dysfunction at 3 months |
||||
|
No (n=136) |
Yes (n=12) |
Difference (95% CI) |
P-value |
|
| Preoperative rScO2 | 66.5 (60.6; 72.0) | 65.0 (58.5; 76.5) | 0.0 (−5.5; 6.5) | 0.97 |
| Mean rScO2 during CPB | 67.2 (61.2; 73.1) | 70.3 (61.5; 72.3) | 1.6 (−4.7; 6.7) | 0.61 |
| Mean rScO2 during surgery | 69.1 (64.5; 73.4) | 69.9 (59.4; 73.6) | 0.2 (−5.4; 4.8) | 0.94 |
| Time below preoperative rScO2 (min) | 59.9 (15.6; 126.3) | 33.2 (17.9; 172.2) | 2.5 (−45.6; 30.1) | 0.80 |
| Time below a 10% decrease from preoperative rScO2 (min) | 4.7 (0.2; 29.6) | 1.0 (0.1; 55.8) | 0.5 (−0.6; 9.8) | 0.53 |
| Time below a 20% decrease from preoperative rScO2 (min) | 0.0 (0.0; 0.8) | 0.0 (0.0; 0.1) | 0.0 (0.0; 0.1) | 0.51 |
| CDL preoperative (% × min) | 236.5 (33.0; 543.3) | 81.0 (41.3; 1046.8) | 22.3 (−87.0; 238.0) | 0.65 |
| CDL10 (% × min) | 7.5 (0.0; 71.5) | 1.8 (0.3; 94.1) | 1.5 (−1.5; 20.0) | 0.42 |
| CDL20 (% × min) | 0.0 (0.0; 1.3) | 0.0 (0.0; 0.4) | 0.0 (0.0; 0.0) | 0.63 |
| Minimum rScO2 value | 55.0 (49.1; 60.5) | 55.3 (48.5; 62.9) | 1.0 (−5.0; 7.0) | 0.70 |
| Maximum rScO2 value | 82.3 (77.0; 87.4) | 83.5 (70.0; 89.1) | 0.0 (−5.5; 6.5) | 0.94 |