Table 3.
Regional cerebral oxygen saturation (rScO2) values for cardiac surgery patients with and without postoperative cognitive dysfunction (POCD) at discharge and at 3 months—high target MAP group. Median with (inter-quartile range) and tested with Mann–Whitney U-test. Differences calculated as independent samples Hodges-Lehmann median difference estimates with 95% confidence intervals (95% CI). CDL, cerebral desaturation load (area under these thresholds); CPB, cardiopulmonary bypass.
|
Postoperative cognitive dysfunction at discharge |
||||
|
No (n=48) |
Yes (n=24) |
Difference (95% CI) |
P-value |
|
| Preoperative rScO2 | 66.0 (61.1; 69.9) | 65.0 (61.5; 71.8) | 0.5 (−3.5; 4.0) | 0.78 |
| Mean rScO2 during CPB | 66.4 (60.6; 71.1) | 64.4 (59.6; 69.1) | 1.8 (−2.3; 5.4) | 0.38 |
| Mean rScO2 during surgery | 68.9 (65.5; 72.8) | 66.6 (60.8; 69.7) | 2.8 (−0.6; 6.2) | 0.12 |
| Time below preoperative rScO2 (min) | 50.0 (10.6; 103.0) | 75.6 (10.6; 137.1) | 41.2 (−9.0; 74.1) | 0.02 |
| Time below a 10% decrease from preoperative rScO2 (min) | 6.7 (0.3; 29.5) | 16.6 (1.3; 65.0) | 5.3 (−0.6; 26.9) | 0.11 |
| Time below a 20% decrease from preoperative rScO2 (min) | 0.1 (0.0; 4.5) | 0.1 (0.0; 6.3) | 0.0 (−0.5; 0.5) | 0.85 |
| CDL preoperative (% × min) | 195.0 (24.8; 486.9) | 392.0 (162.0; 915.5) | 172.3 (2.0; 172.3) | 0.05 |
| CDL10 (% × min) | 10.0 (0.5; 107.0) | 26.8 (1.9; 148.0) | 4.5 (−3.0; 30.0) | 0.24 |
| CDL20 (% × min) | 0.0 (0.0; 6.8) | 0.0 (0.0; 6.1) | 0.0 (0.0; 0.0) | 0.77 |
| Minimum rScO2 value | 53.5 (48.0; 58.9) | 52.5 (46.8; 57.4) | 1.5 (−2.5; 6.0) | 0.44 |
| Maximum rScO2 value |
82.5 (77.5; 86.9) |
81.8 (78.0; 83.9) |
1.0 (−2.0; 4.5) |
0.53 |
|
Postoperative cognitive dysfunction at 3 months |
||||
|
No (n=65) |
Yes (n=4) |
Difference (95% CI) |
P-value |
|
| Preoperative rScO2 | 66.0 (61.0; 71.5) | 65.0 (63.8; 70.8) | 0.0 (−7.5; 6.5) | 0.93 |
| Mean rScO2 during CPB | 65.7 (60.8; 71.0) | 70.5 (69.1; 72.0) | 4.8 (−2.3; 11.0) | 0.12 |
| Mean rScO2 during surgery | 68.8 (64.6; 72.8) | 69.9 (59.36; 73.64) | 1.8 (−3.5; 7.8) | 0.28 |
| Time below preoperative rScO2 (min) | 0.4 (0.1; 1.8) | 31.9 (6.3; 98.7) | 28.9 (−22.8; 98.1) | 0.29 |
| Time below a 10% decrease from preoperative rScO2 (min) | 0.4 (0.1; 1.8) | 12.3 (1.0; 44.1) | 11.7 (−0.1; 49.3) | 0.06 |
| Time below a 20% decrease from preoperative rScO2 (min) | 0.0 (0.3; 0.1) | 0.1 (0.0; 5.9) | 0.1 (−0.1; 7.1) | 0.34 |
| CDL preoperative (% × min) | 80.8 (14.9; 324.8) | 278.0 (62.0; 703.8) | 162.5 (−45.5; 668.5) | 0.20 |
| CDL10 (% × min) | 1.3 (0.3; 2.6) | 21.0 (1.5; 125.5) | 19.3 (0.0; 143.5) | 0.05 |
| CDL20 (% × min) | 0.0 (0.0; 0.0) | 0.0 (0.0; 6.8) | 0.0 (0.0; 7.0) | 0.16 |
| Minimum rScO2 value | 55.3 (51.5; 62.0) | 53.5 (47.8; 58.3) | 3.5 (−4.0; 11.5) | 0.50 |
| Maximum rScO2 value | 84.3 (81.1; 87.4) | 82.5 (77.8; 85.3) | 2.5 (3.0; 2.5) | 0.40 |