Table 3. Diagnostic performance for skin prick test and IgE to peanut, ROC analysis.
Test | Cutoff point | Unadjusted OR (95% CI) | p value | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | AUC |
---|---|---|---|---|---|---|---|---|
SPT (mm) | 3 | 4.68 (2.32–9.41) | <0.0001 | 91.5 | 30.5 | 85.7 | 43.9 | 64.8 |
4 | 7.30 (3.92–13.6) | <0.0001 | 87 | 52.5 | 89.3 | 47 | 68.1 | |
5 | 7.78 (4.22–14.4) | <0.0001 | 81.4 | 64.4 | 91.3 | 43.2 | 67.2 | |
6 | 7.75 (4.12–14.6) | <0.0001 | 74.7 | 72.9 | 92.6 | 38.7 | 65.7 | |
7 | 9.10 (4.55–18.2) | <0.0001 | 68.4 | 81.4 | 94.4 | 36.1 | 65.2 | |
8 | 9.75 (4.52–21.0) | <0.0001 | 61.7 | 86.4 | 95.4 | 33.1 | 64.3 | |
9 | 9.91 (4.23–23.2) | <0.0001 | 54.7 | 89.8 | 96.1 | 30.3 | 63.2 | |
10 | 7.64 (3.06–19.0) | <0.0001 | 43.5 | 91.5 | 95.9 | 26.2 | 61.1 | |
Peanut IgE (kU/L) | 0.35 | 1.96 (0.63–6.11) | 0.2438 | 91 | 15.4 | 89.7 | 17.4 | 53.5 |
2 | 3.50 (1.54–7.97) | 0.0028 | 75.2 | 53.9 | 92.9 | 21.2 | 57.1 | |
5 | 3.07 (1.30–7.26) | 0.0106 | 58.6 | 69.2 | 93.9 | 17.1 | 55.5 | |
6 | 7.41 (2.97–18.5) | <0.0001 | 42.8 | 91.5 | 95.8 | 26 | 60.9 | |
7 | 6.97 (2.80–17.4) | <0.0001 | 41.3 | 91.5 | 95.7 | 25.5 | 60.6 | |
8 | 7.79 (2.88–21.1) | <0.0001 | 38.7 | 93.2 | 96.3 | 25 | 60.6 | |
9 | 6.53 (2.41–17.7) | 0.0002 | 34.6 | 93.2 | 95.9 | 23.8 | 59.8 | |
10 | 3.75 (1.31–10.8) | 0.0138 | 42.9 | 84.6 | 95.7 | 15.5 | 55.6 | |
20 | 6.07 (1.12–32.9) | 0.0364 | 26.2 | 96.2 | 98.2 | 13.9 | 56.1 | |
30 | 12.6 (0.73–218) | 0.0819 | 19.1 | 100 | 100 | 13.3 | 56.6 | |
40 | 9.30 (0.53–164) | 0.1275 | 14.8 | 100 | 100 | 12.7 | 56.3 | |
50 | 7.29 (0.41–130) | 0.1770 | 11.9 | 100 | 100 | 12.3 | 56.2 |
IgE, immunoglobulin E; ROC, receiver operating characteristic; OR, odds ratio; CI, confidence interval; SPT, skin prick test; PPV, positive predictive value; NPV, negative predictive value; AUC, area under the receiver operator characteristic curve.