Table 2.
Presentation and Symptoms of Adult Patients With AMH and its Subgroups Compared With Adult Patients With PCCs Without AMH
| All AMHs (n = 19) | P Value vs PCCs | AMHs Without PCC (n = 7) | P Value vs PCCs | AMHs With PCC (n = 12) | P Value vs PCCs | PCCs Without AMH (n = 95) | |
|---|---|---|---|---|---|---|---|
| Presentation | |||||||
| Incidentaloma, n (%) | 7 (37) | 0.025 | 3 (43) | 0.365 | 4 (33) | 0.021 | 64 (67) |
| Suspicion of PCC, n (%) | 4 (21) | 0.522 | 2 (29) | 0.798 | 2 (17) | 0.288 | 30 (32) |
| Screening, n (%) | 8 (42) | <0.001 | 2 (29) | 0.003 | 8 (67) | <0.001 | 1 (1) |
| PCC symptoms | |||||||
| Paroxysmal symptoms, n (%) | 9 (47) | 0.395 | 2 (29) | 0.198 | 7 (58) | 1 | 58 (61) |
| Headaches, n (%) | 3 (16) | 0.081 | 0 (0) | 0.088 | 3 (25) | 0.365 | 38 (40) |
| Palpitations, n (%) | 7 (37) | 0.175 | 1 (14) | 0.041 | 6 (50) | 0.761 | 54 (57) |
| Sweating, n (%) | 5 (26) | 0.234 | 3 (43) | 0.745 | 2 (17) | 0.117 | 42 (44) |
| Pallor, n (%) | 2 (11) | 0.777 | 0 (0) | 0.871 | 2 (17) | 0.357 | 9 (9) |
| Anxiety, n (%) | 8 (42) | 0.867 | 2 (29) | 0.569 | 6 (50) | 1 | 45 (47) |
| Feeling warm/flush, n (%) | 2 (11) | 0.311 | 2 (29) | 0.844 | 0 (0) | 0.066 | 23 (24) |
| Nausea, n (%) | 1 (5) | 0.226 | 1 (14) | 0.900 | 0 (0) | 0.119 | 19 (20) |
| Weight loss, n (%) | 1 (5) | 0.399 | 0 (0) | 0.588 | 1 (8) | 0.689 | 15 (16) |
| Tiredness, n (%) | 5 (26) | 0.926 | 3 (43) | 0.705 | 2 (17) | 0.507 | 27 (28) |
| Tremor, n (%) | 1 (5) | 0.457 | 0 (0) | 0.600 | 1 (8) | 0.547 | 14 (15) |
| Orthostatic symptoms, n (%) | 0 (0) | 0.037 | 0 (0) | 0.312 | 0 (0) | 0.066 | 23 (24) |
| Number of PCC symptoms | 2.0 (0.3–3.0) | 0.031 | 1.0 (0–3.0) | 0.049 | 2.0 (1.0–3.5) | 0.267 | 3.0 (1.0–5.0) |
| Classic triad, n (%) | 1 (5) | 0.195 | 0 (0) | 0.389 | 1 (8) | 0.453 | 20 (21) |
| Cushing symptoms,a n (%) | 2 (11) | 0.114 | 2 (29) | 0.003 | 0 (0) | 1 | 1 (1) |
| Asymptomatic, n (%) | 5 (26) | 0.097 | 3 (43) | 0.042 | 1 (8) | 1 | 9 (9) |
The patients screened due to familiar disease had a previously known RET mutation (MEN2A). The classic triad with paroxysmal symptoms was defined as headaches, sweating, and palpitation. Boldface indicates P < 0.05; italics indicate P = 0.05–0.09.
a
Symptoms that could indicate Cushing syndrome (e.g., moon face, fat deposition at the supraclavicular fossa/between the shoulders/abdomen, acne, skin atrophy, depression, fatigue, insomnia, concentration difficulties, easy bruising, proximal muscle weakness, muscle and joint pain, and amenorrhea).