Table 4.

Changes in Anthropometric and Metabolic Parameters With Metreleptin

	Change After 2 Wka	Change After 6 Mob
Weight, kg	−0.88 ± 1.2c	−2.9 ± 2.7c
BMI, kg/m2	−0.29 ± 0.43c	−1.1 ± 0.94c
Body fat, %	−0.35 ± 0.76	−1.1 ± 1c,d
Total cholesterol, mg/dL	−33 (−105.8, −14.6)c	−101.6 ± 95.6c
HDL-C, mg/dL	−0.88 ± 4.4	2.5 ± 7.6
LDL-C, mg/dL	−10.3 (−28.9, 18.4)e	−16 (−40, −15.5)f
LDL-C, mg/dL, by NMR	−5.9 ± 23.0	−22.3 ± 12.8c
TG, mg/dL	−138.3 (−692.5, −60.5)c	−225.5 (−2358, −49)c
HOMA-IR	−1.6 (−9.4, 0.57)	−0.64 (−13.7, 0.30)
Fasting glucose, mg/dL	−18.8 ± 26.2c	−63.5 ± 85.3c

Values are means ± SD for normally distributed data and median (25th percentile, 75th percentile) for variables without normal distribution.

^aDay 0 to day 14.

^bDay −5 to 6 mo.

^c P < 0.05.

^dBody fat percentage was not done at day −5, so the 6-mo time point was compared with day 0.

^en = 6.

^fn = 5.