Table I.
Effect of taraxasterol on histopathological score, p53 IHC score and expression of TNF-α and IL-6 in vivo.
| Group | n | Histopathological score | p53 IHC score | IL-6 (pg/ml) | TNF (pg/ml) |
|---|---|---|---|---|---|
| Model | 12 | 9.12±1.12 | 16.27±2.12 | 271.36±24.28 | 342.182±24.283 |
| 25 mg/kg | 12 | 7.43±1.02 | 13.28±1.87 | 215.37±24.28c | 254.281±24.283c |
| 50 mg/kg | 12 | 5.38±0.93 | 10.27±1.68 | 162.27±24.28b,c | 182.472±24.283b,c |
| 100 mg/kg | 12 | 4.58±0.98 | 9.12±1.57 | 135.21±24.28a–c | 152.811±16.482a–c |
| Control | 12 | 1.95±0.47 | 5.27±1.20 | 69.26±11.45a | 83.127±9.281a |
a
P<0.05 vs. model group
b
P<0.05 vs. the 25 mg/kg taraxasterol group
c
P<0.05 vs. control group. p53, tumor protein p53; IHC, immunohistochemistry; TNF-α, tumor necrosis factor alpha; IL-6, interleukin 6.