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. 2019 Jul 8;18(3):1677–1684. doi: 10.3892/etm.2019.7745

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Copyright: © Cai et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 3. — Histological features and scoring for structural damage in mouse knee articular cartilage 4 weeks following DMM model establishment. OA was induced in B6 mice following surgical DMM, and 7,8-DHF or vehicle was subsequently administered by intraperitoneal injection. (A) Representative frontal sections (6-µm) were stained with Safranin O/Fast Green (n=10 mice per group). Images were captured at ×200 magnification. Arrows indicate the damage-affected cartilage areas. Scale bars=100 µm. (B) Histological scoring of OA. *P<0.05 compared with the OA group. 7,8-DHF, 7,8-dihydroxyflavone; OA, osteoarthritis; DMM, destabilization of the medial meniscus.