Figure 1.

Elevated expression of Dio2 in intestinal polyps of Apc ^Δ716 mice. A, Schematic diagram of deiodination of thyroxine (T4). DIO, iodothryonine deiodinase; I, iodine atom; rT3, 3,3′,5′‐triiodo‐l‐thyronine; T2, 3,3′‐diiodo‐l‐thyronine; T3, 3,3′,5‐triiodo‐l‐thyronine. B, Heat map of DNA microarray data of small intestinal (SI) normal mucosa and polyps (n = 3, each group). Colors were coded according to Z‐scored signal intensity. Thra, thyroid hormone receptor, α; Thrb, thyroid hormone receptor, β. C, Expression of Dio2 in normal and polyp tissues from Apc ^Δ716 mice analyzed by real‐time RT‐PCR. CN, normal colon; CP, colonic polyps; SN, normal small intestine; SP, small intestinal polyps. SN and SP, n = 7, P‐value = 9.56 × 10⁻⁵ by paired 2‐tailed t test on log‐transformed data. CN and CP, n = 8, P‐value = 8.99 × 10⁻⁶. ***P < .001 compared with SN or CN