Figure 4.

Chemical thyroidectomy suppresses intestinal tumor formation. A, Schematic diagram of the schedule of chemical thyroidectomy with 2‐mercapto‐1‐methyl‐imidazole (MMI) and potassium perchlorate (PP). B, H&E staining of thyroid glands 3 mo after chemical thyroidectomy. Body weight of control and MMI + PP‐treated Apc ^Δ716 mice. Box plots of the final body weight of the mice immediately before sampling. Control, 22.8 ± 1.6 g, n = 9; MMI + PP, 22.7 ± 2.3 g, n = 9. Welch 2‐tailed t test, P = 0.897; ns, not significant. Bars: 50 μm. C, H&E staining of polyp tissues from control (CNT) and MMI + PP‐treated Apc ^Δ716 mice. Bars: 100 μm. D, Number of total and large‐size polyps (≥1.5 mm) in CNT and MMI + PP‐treated Apc ^Δ716 mice. Total polyps: CNT, 174 ± 49, n = 9; MMI + PP, 97 ± 35, n = 9; Welch 2‐tailed t test, P = .00178. Large‐size polyps: CNT, 63 ± 37, n = 9; MMI + PP, 12 ± 8, n = 9. P = .00317. **P < .01 compared with CNT