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Established 5‐fluorouracil (5‐FU)‐resistant cell growth in human colorectal cancer cell line. A, Effect of 5‐FU on cell growth of parent and 5‐FU‐resistant cells at various concentrations. Cell numbers after treatment with 5‐FU were evaluated using the trypan‐blue dye exclusion test. B, Cell cycle distribution of parent and 5‐FU‐resistant cells. C, The expression of cell cycle‐related protein in parent and 5‐FU‐resistant cells
