Table 2.
Radiosensitization activity of Fadu and Detroit562 cells silenced IRE1 with antisense siRNA
| Fadu | Detroit562 | |||
|---|---|---|---|---|
| Neg siRNA | IRE1 siRNA | Neg siRNA | IRE1 siRNA | |
| D0 | 1.70 | 1.33 | 1.46 | 1.21 |
| Dq | 1.99 | 1.73 | 1.77 | 1.40 |
| N | 4.32 | 4.25 | 4.04 | 3.24 |
| SF2 | 0.79 | 0.66 | 0.69 | 0.50 |
| SER | 1.28 | 1.21 | ||
| SD | ||||
| 2 Gy | 0.04 | 0.05 | 0.03 | 0.02 |
| 4 Gy | 0.09 | 0.04 | 0.05 | 0.04 |
| 6 Gy | 0.02 | 0.02 | 0.01 | 0.01 |
Abbreviations: D0, mean lethal dose; Dq, quasi‐threshold dose; N, extrapolation number, derived directly from the fitting equation; SER, sensitization enhancement ratio; SF2, survival fraction (2 Gy).