Table 2.
Multivariate Cox regression analysis on overall survival (OS) and disease‐free survival (DFS) in patients with pancreatic ductal adenocarcinoma
| Parameters | OS | |||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| Age | 1.291 | 0.899‐1.854 | 0.166 | |||
| Gender | 0.991 | 0.684‐1.434 | 0.960 | |||
| Tumor sites | 1.181 | 0.772‐1.806 | 0.442 | |||
| Nerve invasion | 1.089 | 0.745‐1.592 | 0.661 | |||
| Grade | 1.476 | 1.182‐1.843 | 0.001 | 1.293 | 1.021‐1.637 | 0.033 |
| pT | 1.345 | 1.042‐1.736 | 0.023 | 1.314 | 1.002‐1.723 | 0.048 |
| pN | 1.715 | 1.289‐2.283 | <0.0001 | 1.385 | 1.020‐1.882 | 0.037 |
| PIN1 | 2.165 | 1.469‐3.190 | <0.0001 | 1.621 | 1.062‐2.447 | 0.025 |
| Parameters | DFS | |||||
|---|---|---|---|---|---|---|
| Univariate analysis | Multivariate analysis | |||||
| HR | 95% CI | P‐value | HR | 95% CI | P‐value | |
| Age | 1.17 | 0.838‐1.633 | 0.356 | |||
| Gender | 1.082 | 0.768‐1.523 | 0.653 | |||
| Tumor sites | 1.163 | 0.779‐1.736 | 0.460 | |||
| Nerve invasion | 1.177 | 0.825‐1.678 | 0.368 | |||
| Grade | 1.399 | 1.148‐1.704 | 0.001 | 1.282 | 1.045‐1.572 | 0.017 |
| pT | 1.45 | 1.140‐1.846 | 0.003 | 1.397 | 1.083‐1.802 | 0.01 |
| pN | 1.718 | 1.328‐2.222 | <0.0001 | 1.472 | 1.121‐1.933 | 0.005 |
| PIN1 | 1.841 | 1.299‐2.609 | 0.001 | 1.436 | 0.994‐2.073 | 0.05 |
Multivariate analysis: adjusted by histological grade, pT, pN and PIN1 expression.