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. 2019 Jul 12;110(8):2368–2377. doi: 10.1111/cas.14110

Figure 4.

Figure 4

Hypoxia decreases transcription of microRNA (miR)‐30c in macrophages due to hypoxia‐inducible factor (HIF)‐1α activation. A,B, THP‐1 cells were treated as indicated. miR‐30c transcription was monitored by using real‐time PCR (A), and the expression of HIF1‐α was detected by using western blot analysis (B). C, Luciferase reporter assay using both WT and mutated (MU) 3′UTR. CPT, cryptotanshinone. Data are presented as mean ± SD. **P < .01, Student's t test