Table 2.

Daratumumab serum concentrations with single vs split first dose in the all treated population

	Postfirst dose		C3 D1 preinfusion	C3 D1 end of infusion
	C1 D1 end of infusion	C1 D2 end of infusion
Single first dose
Patients, n	8	—	9	9
Mean daratumumab serum concentration, μg/mL (SD)	321.14 (49.0)		517.46 (137.2)	895.61 (169.5)
CV, %	15.3	—	26.5	18.9
Geometric mean daratumumab serum concentration, μg/mL	317.73		502.54	882.53
Split first dose
Patients, n	—	69	52	52
Mean daratumumab serum concentration, μg/mL (SD)		255.03 (71.87)	618.53 (256.2)	951.44 (350.1)
CV, %	—	28.2	41.4	36.8
Geometric mean daratumumab serum concentration, μg/mL		244.90	549.57	855.74

C, cycle; CV, coefficient of variation; D, day; SD, standard deviation.