Figure 3.

In situ investigation of infiltration of CD8⁺ and programmed cell death‐1 (PD‐1)⁺ lymphocytes into pancreatic carcinoma lesions. A,B, Comparison of infiltration of CD8⁺ cells in the tumor (A) and interstitial tissue (B) between patients who had and had not received the survivin 2B peptide (SVN‐2B) vaccine. C, Number of CD8⁺ lymphocytes that infiltrated each tumor lesion. D,E, Comparison of infiltration of PD‐1⁺ cells into the tumor (D) and interstitial tissue (E) between patients who had and had not received the SVN‐2B vaccine. F, Number of PD‐1⁺ lymphocytes that infiltrated each lesion. G,H, Correlation between proportions of the PD‐L1⁺ tumor and CD8⁺ (G) or PD‐1⁺ (H) lymphocyte infiltration in the lesions. PD‐L1 expression on the surface of tumor cells was deemed to be positive. Signal intensity was not evaluated