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SIRT1 was revealed to be a target gene of miR-448. (A) Sequence alignment revealed that there was a complementary binding site for miR-448 on the 3′ untranslated region of SIRT1 mRNA. (B) Transfection of miR-448 mimics reduced relative luciferase activity in A549 cells transfected with SIRT1 3′UTR-WT. **P<0.01 vs. miR-NC mimics. miR, miroRNA; SIRT1, sirtuin1; NC, negative control; WT, wild type; Mut, mutant.
