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. 2019 Aug 1;15:1744806919868380. doi: 10.1177/1744806919868380

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — Box5 abolished the activation of astrocytes induced by gp120 and morphine. (a) Immunoblots of GFAP and p-JNK. (b and c) Quantitative summary of panel (a). (d) Immunostaining of GFAP in the SDH. Mice were administrated with gp120 and morphine as described in Figure 1(a), except that Box5 (16 µg, Wnt5a antagonist) was i.t. injected 30 min before gp120/morphine administration. The regions shown in the representative micrograph were indicated by the box in the scheme on the left. (e) Quantification of GFAP⁺ cells in the SDH of panel (d) (*p < 0.05; **p < 0.01; ***p < 0.001; one-way analysis of variance with Tukey post hoc tests, n = 3). GFAP: glial fibrillary acidic protein; JNK: c-Jun N-terminal kinase.