Table 2.
Invasive haemodynamics at rest versus peak exercise in MACE versus no‐MACE HTx patients
| Rest | Peak exercise | |||||
|---|---|---|---|---|---|---|
| MACE (n = 26) | No MACE (n = 48) | P value | MACE (n = 25) | No MACE (n = 45) | P value | |
| Peak exercise METs (mL/kg/min) | 5.7 ± 1.5 | 6.0 ± 1.3 | 0.43 | |||
| Heart rate (beats/min) | 86 ± 16 | 84 ± 12 | 0.62 | 137 ± 17 | 129 ± 16 | <0.05 |
| MAP (mmHg) | 103 ± 12 | 99 ± 11 | 0.14 | 131 ± 18 | 127 ± 19 | 0.34 |
| AV diff (%) | 29 ± 6 | 27 ± 4 | 0.12 | 68 ± 9 | 64 ± 12 | 0.15 |
| SVRI (dynes/s/cm5/m2) | 2991 ± 565 | 2753 ± 558 | 0.08 | 1682 ± 485 | 1554 ± 474 | 0.34 |
| CI (L/min/m2) | 2.6 ± 0.4 | 2.8 ± 0.5 | 0.07 | 5.8 ± 1.6 | 6.4 ± 1.6 | 0.14 |
| SVI (mL/m2) | 32 ± 8 | 34 ± 7 | 0.23 | 42 ± 10 | 50 ± 12 | <0.01 |
| mRAP (mmHg) | 6 ± 4 | 4 ± 2 | <0.01 | 17 ± 10 | 11 ± 4 | <0.01 |
| mPAP (mmHg) | 21 ± 8 | 17 ± 4 | 0.08 | 38 ± 9 | 36 ± 7 | 0.28 |
| mPCWP (mmHg) | 12 ± 6 | 9 ± 3 | <0.05 | 28 ± 9 | 22 ± 9 | <0.01 |
| TPG (mmHg) | 9 ± 5 | 8 ± 3 | 0.43 | 10 ± 8 | 13 ± 7 | <0.05 |
| PVR (wood units) | 1.9 ± 1.4 | 1.5 ± 0.6 | 0.47 | 1.0 ± 1.0 | 1.2 ± 0.7 | 0.15 |
| PAC (mL/mmHg) | 4.9 ± 2.0 | 5.7 ± 2.2 | 0.09 | 3.9 ± 1.8 | 4.6 ± 1.8 | 0.17 |
Data are presented as mean ± standard deviation. AV diff, arterial‐venous saturation difference; CI, cardiac index; HTx, heart‐transplanted; MACE, major adverse cardiac events; mPAP, mean pulmonary arterial pressure; mPCWP, mean pulmonary capillary wedge pressure; mRAP, mean right atrial pressure; PAC, pulmonary arterial compliance; PVR, pulmonary vascular resistance; SVI, Stroke Volume Index; SVRI, Systemic Vascular Resistance Index; TPG, transpulmonary pressure gradient.