Table 5.

Summary of the studies investigating the ability of SENC to assess myocardial strain in the right ventricle of normal subjects and patients with pulmonary hypertension (PH)

First author, journal, and year of publication	Number of healthy subjects	Number of patients with PH	Single‐heartbeat acquisition	Comparison with LGE	Comparison with 2D echo	Inter‐observer variability	Intra‐observer variability
Youssef et al., JMRI, 2008	21	None	No	No	No	r = 0.80	r = 0.88
Handam et al., JMRI, 2008	12	None	No	No	No	r = 0.89a	NA
						r = 0.94b
Shehata et al., MRM, 2010	11	11	Yes	No	No	0.2% ± 5.3%	0.3% ± 5.4%
Shehata et al., AJR, 2011	None	32	Yes	Yes	No	NA	NA
Oyama‐Manabe et al., Int. J. Cardiovasc. Imaging, 2013	13	37	Yes	No	No	c	c
Freed et al., Echocardiography, 2014	None	30	Yes	No	Yes	10%	13%
Ohyama et al., IJC, 2015	15	30	No	No	No	d	d

LGE, late gadolinium enhancement; NA, not applicable.

^aFor peak longitudinal strain.

^bFor peak circumferential strain.

^cLow inter‐observer and intra‐observer variability is demonstrated by Bland–Altman plots. Correlation coefficients are not provided.

^dObserver variability provided only for feature tracking imaging. The discriminatory capacity of SENC was superior to that provided by feature tracking imaging for the detection of right ventricular dysfunction in patients with PH.