Table 3.
Diagnostic yield of LAD in relation to ASE‐recommended diastolic indices or DD and ESC NT‐proBNP cut‐offs for HF
| C‐statistics | LAD | |||||||
|---|---|---|---|---|---|---|---|---|
| Odds ratio (95% CI) | AUROC | 95% CI | Cut‐off (mm) | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | |
| NT‐proBNP Abn (≥125 pg/mL) | 2.34 [1.85, 2.94] | 0.63 | [0.59, 0.66] | 34 | 50.5 | 69.6 | 50.49 | 69.62 |
| Echocardiography indices by ASE | ||||||||
| LAVi Abn (also ESC HFpEF16) | 2.24 [1.70, 2.96] | 0.57 | [0.54, 0.61] | 37 | 25.60 | 86.70 | 96 | 8 |
| TDI e′ (both) Abn | 2.45 [2.19, 2.73] | 0.65 | [0.64, 0.66] | 31 | 61.10 | 61.20 | 66.10 | 55.60 |
| TDI E/e′ Abn | 2.85 [2.17, 3.74] | 0.68 | [0.64, 0.71] | 32 | 67.30 | 58.40 | 7.50 | 95.20 |
| TR velocity Abn | 5.50 [4.41, 6.84] | 0.74 | [0.71, 0.77] | 35 | 62.10 | 77.20 | 11.60 | 95.40 |
| DD Abn by ASE | ||||||||
| All | 6.27 [4.47, 8.81] | 0.77 | [0.73, 0.80] | 34 | 74 | 68.80 | 5.30 | 97.90 |
| Women | 11.48 [6.70, 19.68] | 0.81 | [0.77, 0.85] | 31.6 | 86.50 | 70 | 8.70 | 96.80 |
| Men | 6.46 [3.65, 11.41] | 0.77 | [0.71, 0.83] | 34 | 82.60 | 63.70 | 3.20 | 98.60 |
| ESC criteria for HFpEF16 | 3.86 [2.70, 5.52] | 0.70 | [0.65, 0.75] | 35 | 53.6 | 77.0 | 4.9 | 98.7 |
Abn, abnormal; ASE, American Society of Echocardiography; AUROC, area under receiver operating characteristic curve; CI, confidence interval; DD, diastolic dysfunction; ESC, European Society of Cardiology; HF, heart failure; HFpEF, heart failure with preserved ejection fraction; LAD, left atrial dimension; LAVi, left atrial volume index; NPV, negative predictive value; NT‐proBNP, N‐terminal pro‐brain natriuretic peptide; PPV, positive predictive value; TDI, tissue Doppler imaging; TR, tricuspid regurgitation.