Table 1.

FDA Dosing Recommendations for Thrombopoietin Receptor Agonists

Agent	Population	Dosing	Timing
Eltrombopag	Contraindicated in cirrhotic patients	N/A	N/A
Avatrombopag	Cirrhotic patients with platelet counts 40-50 × 109/L	40 mg daily for 5 days	Initiate dosing 10-13 days prior to procedure.
	Cirrhotic patients with platelet counts <40 × 109/L	60 mg daily for 5 days	Initiate dosing 10-13 days prior to procedure.
Lusutrombopag	Cirrhotic patients with platelet counts <50 × 109/L	3 mg daily for 7 days	Initiate dosing 8-14 days prior to procedure.

FDA, US Food and Drug Administration; N/A, not applicable.