Table 4.
Amino acid substitution reported in E1 gene among Indian strains and the effect of some of the mutations on virulence as reported.
| Author | Reference | Mutations reported | Effect of mutations |
|---|---|---|---|
| Schuffenecker et al. 2006 | 6 | A226V and D284E | A226V: Leads to increased fitness, midgut infectivity dissemination to the salivary glands and transmissibility of the virus by Aedes albopictus mosquitoes |
| Arankalle et al. 2007 | 27 | V19I, K211N, V213I, M269V, D284E, A377T | M269V: Increased transmissibility of the virus |
| Santhosh et al. 2008 | 29 | V14A and A226V | A226V: as above |
| Niyas et al. 2010 | 15 | A226V and V291I | A226V: as above |
| Sreekumar et al. 2010 | 30 | V04A, E127G, D184G, Y195H, M197V, A226V, G248E, D284E, P304L, T396A, K411R, C433R | A226V: as above |
| Shrinet et al. 2012 | 25 | K211E, M269V, D284E, V179A, S234P, R196K and R247C | M269V: Increased transmissibility of the virus |
| Mudurangaplar et al. 2016 | 24 | K211E, M269V and D284E | -do- |
| Present study | M269V, D284E, K211E, T145A, N149K, G150D and G314A | M269V: increased transmissibility of the virus. Further studies will be required to determine the effect of the new mutations |