Table 2.

Descriptive statistics for original COMBINE drinking data and simulated drinking data.

	Baseline mean PHDD	Post-treatment mean PHDD	PHDD Effect size for naltrexone versus placebo (Cohen’s d)	Percent decrease in Cohen’s d from COMBINE data	Baseline NHDD	Post-treatment NHDD	NHDD Effect size for naltrexone versus placebo (Cohen’s h)	Percent decrease in Cohen’s h from COMBINE data
COMBINE data	0.616	0.182	−0.088	−	0.005	0.430	−0.055	−
Simulation 1 data:	0.526	0.155	−0.089	−1%	0.053	0.502	−0.055	0%
mean = 1.24
drinks
Simulation 2 data:	0.482	0.134	−0.084	5%	0.073	0.546	−0.048	13%
mean = 1.41
drinks
Simulation 3 data:	0.435	0.115	−0.078	11%	0.098	0.589	−0.042	24%
mean = 1.59
drinks
Simulation 4 data:	0.389	0.098	−0.073	17%	0.129	0.632	−0.036	35%
mean = 1.77
drinks
Simulation 5 data:	0.344	0.084	−0.065	26%	0.166	0.672	−0.028	49%
mean = 1.95
drinks
Simulation 6 data:	0.303	0.070	−0.056	36%	0.207	0.710	−0.019	65%
mean = 2.14
drinks

Note: PHDD = percent heavy drinking days; NHDD = percent subjects with no heavy drinking days