Table 4.
Summary table of the pathways significantly upregulated in the Hallmark GSEA. The FDR 25% was the significance level cut off (FDR q < 0.25) only upregulated pathways were significant in both GSTCD SiRNA B and SiRNA C gene lists and there were no significantly different pathways with an FDR below 10%
| Upregulated Pathways | Number of genes in pathway | Number of Significant genes for B and C (%) | B FDR q-val | C FDR q-val |
|---|---|---|---|---|
| Adipogenesis | 196 | 46 (23) | 0.013 | 0.012 |
| Bile Acid Metabolism | 112 | 15 (13) | 0.1 | 0.061 |
| Estrogen Response early | 199 | 34 (17) | 0.16 | 0.00081 |
| Fatty Acid Metabolism | 158 | 24 (15) | 0.16 | 0.045 |
| Oxidative Phosporylation | 199 | 62 (31) | 0.037 | 0 |
| P53 Pathway | 199 | 46 (23) | 0.1 | 0.0007 |
| Peroxisome | 103 | 29 (28) | 0.2 | 0.038 |
| Reactive Oxygen Species Pathway | 47 | 12 (25) | 0.1 | 0.061 |