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. 2019 Aug 1;10:231. doi: 10.1186/s13287-019-1352-4

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Characterization of MSC-derived NVs. a TEM image of purified NVs. Scale bar, 100 nm. b Size distribution of NVs according to diameter. c The number of particles per proteins of NVs measured by nanoparticle tracking analysis (n = 3). d Top 10 subcellular localization GO terms enriched in NV proteome (based on P value). Three biological replicates were used, and commonly identified proteins in three runs were analyzed for GO terms. e Western blot analysis of EV markers on NV (10 μg) and MSC lysates (25 μg)