Table III.
Change of OFV of covariate analysis.
| A, Inclusion | |||
|---|---|---|---|
| Model description | OFV | Changed OFV | P-value |
| Base model | 632.127 | n/a | n/a |
| Influence of DTT on V/F | 612.162 | −19.965 | <0.05 |
| Influence of age on CL/F | 600.137 | −12.025 | <0.05 |
| Influence of ALT on CL/F | 594.447 | −5.69 | <0.05 |
| Influence of sex on CL/F | 577.809 | −16.638 | <0.05 |
| B, Elimination | |||
| Model description | OFV | Changed OFV | P-value |
| Full model | 577.809 | n/a | n/a |
| Eliminate DTT on V/F | 585.027 | 7.218 | <0.01 |
| Eliminate age on CL/F | 591.406 | 13.597 | <0.01 |
| Eliminate ALT on CL/F | 599.727 | 21.918 | <0.01 |
| Eliminate sex on CL/F | 594.447 | 16.638 | <0.01 |
ALT, alanine transaminase; CL/F, apparent oral clearance (l/h); DTT, duration of treatment with sirolimus; OFV, objective function values; V/F, apparent volume of distribution (l).