Table IV.
Bootstrap | |||||
---|---|---|---|---|---|
Parameter | Estimate | SE (%) | Median | 95% CI | Bias (%) |
CL/F (l/h) | 3.19 | 23.7 | 3.21 | [1.83, 5.46] | 0.63 |
V/F (liters) | 165 | 26.9 | 159 | [56.12, 389.07] | −3.64 |
Ka (h−1) | 0.485 (fixed) | – | – | – | – |
θAGE | 0.215 | 21.7 | 0.21 | [0.09, 0.35] | −4.65 |
θALT | 0.0108 | 18 | 0.01 | [-0.01, 0.014] | 2.78 |
θSEX | −0.818 | 15.4 | −0.8 | [-1.08, −0.52] | −2.51 |
θDTT | 0.0783 | 7.8 | 0.08 | [0.02, 0.1] | 1.15 |
ωCL/F | 0.217 | 20.7 | 0.19 | [0.06, 0.26] | −13.13 |
ωV/F | 1.334 | 15.2 | 1.19 | [0.67, 1.86] | −11.02 |
σ1 | 0.365 | 6.8 | 0.36 | [0.31, 0.4] | −1.78 |
SE, standard error. The 95% CI was presented as the 2.5th and 97.5th percentile of bootstrap estimates. Bias = (median-estimate)/estimate ×100%. θAGE, coefficient of the age; θALT, coefficient of the alanine transaminase; θDTT, coefficient of the duration of treatment with sirolimus; θSEX, coefficient of the sex; ωCL/F, inter-individual variability of CL/F; ωV/F, inter-individual variability of V/F; σ1, residual variability; Bias, prediction error; CI, confidence interval; CL/F, apparent oral clearance (l/h); Ka, absorption rate constant (h−1); V/F, apparent volume of distribution (l).