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. 2019 Jul 4;18(3):2412–2419. doi: 10.3892/ol.2019.10562

Table IV.

Parameter estimates of the final model and bootstrap validation.

Bootstrap

Parameter Estimate SE (%) Median 95% CI Bias (%)
CL/F (l/h) 3.19 23.7 3.21 [1.83, 5.46] 0.63
V/F (liters) 165 26.9 159 [56.12, 389.07] −3.64
Ka (h−1) 0.485 (fixed)
θAGE 0.215 21.7 0.21 [0.09, 0.35] −4.65
θALT 0.0108 18 0.01 [-0.01, 0.014] 2.78
θSEX −0.818 15.4 −0.8 [-1.08, −0.52] −2.51
θDTT 0.0783 7.8 0.08 [0.02, 0.1] 1.15
ωCL/F 0.217 20.7 0.19 [0.06, 0.26] −13.13
ωV/F 1.334 15.2 1.19 [0.67, 1.86] −11.02
σ1 0.365 6.8 0.36 [0.31, 0.4] −1.78

SE, standard error. The 95% CI was presented as the 2.5th and 97.5th percentile of bootstrap estimates. Bias = (median-estimate)/estimate ×100%. θAGE, coefficient of the age; θALT, coefficient of the alanine transaminase; θDTT, coefficient of the duration of treatment with sirolimus; θSEX, coefficient of the sex; ωCL/F, inter-individual variability of CL/F; ωV/F, inter-individual variability of V/F; σ1, residual variability; Bias, prediction error; CI, confidence interval; CL/F, apparent oral clearance (l/h); Ka, absorption rate constant (h−1); V/F, apparent volume of distribution (l).