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. 2019 Jul 4;18(3):2537–2547. doi: 10.3892/ol.2019.10560

Figure 5.

Figure 5.

Effect of paclitaxel combined with cisplatin on apoptosis and Wnt/β-catenin signaling-associated proteins expression. C666-1 cells were incubated with indicated paclitaxel combined with cisplatin or XAV949 for 48 h. Immunoblots and bar graphs of indicated proteins levels of C666-1 cells. (A) Change in total caspase-3 and active caspase-3 expression following paclitaxel following paclitaxel combined with cisplatin or XAV949 treatment. (B) Change in BCL-2 expression following paclitaxel combined with cisplatin or XAV949 treatment. (C) Change in β-catenin expression following paclitaxel combined with cisplatin or XAV949 treatment. (D) Change in c-Myc expression following paclitaxel combined with cisplatin or XAV949 treatment. Data are presented as mean ± standard error of the mean of three independent experiments. One-way analysis of variance, followed by Dunnett's multiple-comparisons test, was utilized for analyzed differences among groups. **P<0.01 vs. control group. Bcl2, B-cell lymphoma.