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. 2019 Jun 27;18(3):2304–2309. doi: 10.3892/ol.2019.10531

Figure 3.

Figure 3.

Loss of 5-hmC is associated with malignant potential of PTC. (A) Analysis of 5-hmC levels between PTCs with N+ (n=45) and N− (n=43), represented by H-score (left). Spearman correlation analysis between 5-hmC staining and the number of metastatic lymph nodes (right). At least three tissue sections were analyzed for each case. (B) Representative IHC staining of 5-hmC in the individual cases of PTC with N− and PTC with N+. Left: Low-power images (magnification, ×200); scale bars, 100 µm. Right: High-power images (magnification, ×400); scale bar, 50 µm. (C) Pearson correlation analysis between 5-hmC staining and tumor size (left). Analysis of 5-hmC levels between macro-carcinoma with N− (n=21) and micro-carcinoma with N+ (n=22), represented by H-score (right). At least three tissue sections were analyzed for each case. Data are presented as the mean ± standard error. 5-hmC, 5-hydroxymethylcytosine; PTC, papillary thyroid carcinoma; 5- N+, lymph node metastases; N−, no lymph node metastases.