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Metformin sensitizes SKOV3 and SKOV3/DDP cells to chemotherapeutic agents.
| IC50 (µg/ml) | ||||
|---|---|---|---|---|
| Cell | Drug | Metformin− | Metformin+ | Ratioa |
| SKOV3 | MTX | 4.21 | 2.80 | 1.50 |
| DDP | 14.35 | 11.20 | 1.28 | |
| SKOV3/DDP | MTX | 15.27 | 2.47 | 6.18 |
| DDP | 70.26 | 6.21 | 11.31 | |
Ratio=IC50 for Metformin−/IC50 for Metformin+. IC50, half-inhibitory concentration; DDP, cisplatin; MTX, methotrexate.
