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. 2019 Jul 5;18(3):2509–2517. doi: 10.3892/ol.2019.10574

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Copyright: © Tang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — TIGAR is overexpressed in glioblastoma tissues and is associated with poor survival. (A) Immunohistochemical staining of TIGAR indicated that, compared with adjacent normal tissues, TIGAR was overexpressed in glioblastoma tissues. Scale bar, 200 µm in replicate images and 50 µm in enlarged image. (B) Quantitative analysis of TIGAR staining between normal and tumor tissues (n=15). (C) Protein lysates prepared from five human glioblastoma cell lines were immunoblotted with anti-TIGAR antibody, and TIGAR was revealed to be overexpressed in U-87MG cells. (D) Kaplan-Meier analysis of overall survival in patients with brain cancer (GSE4412-GPL96) with high or low TIGAR mRNA expression revealed that high expression levels of TIGAR were associated with shorter survival times. These data were obtained from PrognoScan. Data in panel B are expressed as the mean ± standard deviation. TIGAR, TP53 induced glycolysis regulatory phosphatase.