Table V.

Selection of the toxicities of principal available drugs for soft tissue sarcomas.

	Frequency of toxicities
Drug	Very common and common	Uncommon	Rare and very rare
Doxorubicin	Myelosuppression, Cardiotoxicity	Dehydration	Tissue necrosis
Ifosfamide	Myelosuppression, Hepatotoxicity, Hemorrhagic cystitis, Acute renal failure	Peripheral neuropathy, Stomatitis	CNS toxicity, Dermatitis
Gemcitabine	Myelosuppression, Elevation of liver transaminases, Allergic skin rash, Influenza-like symptoms	Interstitial pneumonitis	Anaphylactoid reaction, PRES, Capillary leak syndrome
Docetaxel	Myelosuppression, Hypersensitivity, Peripheral neuropathy, Fluid retention	Arthralgia, Elevation of liver transaminases	Cardiotoxicity
Trabectedin	Myelosuppression, Elevation of liver transaminases, PPEDS	Capillary leak syndrome, Pulmonary edema	Hepatic failure
Pazopanib	Hypothyroidism, Hypertension, Hair color change, Elevation of liver transaminases, Diarrhea	Hypomagnesaemia, Retinal detachment, Cardiotoxicity, Intestine perforation	Thrombotic microangiopathy, Posterior reversible encephalopathy, Pneumonitis

The following was utilized for the classification of frequency: Very common ≥1/10; common ≥1/100 to <1/10; uncommon ≥1/1,000 to <1/100; rare ≥1/10,000 to <1/1,000; and very rare <1/10,000). CNS, Central nervous system; PRES, Posterior reversible; encephalopathy syndrome; PPEDS, Palmar-plantar erythrodysesthesia syndrome.