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. 2019 Jul 4;18(3):2394–2403. doi: 10.3892/ol.2019.10559

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Copyright: © Jin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 2. — Mature NK cell populations are altered in both Notch1-T-ALL mice and patients with T-ALL. Freshly isolated splenocytes were obtained from Notch1-T-ALL mice or control WT C57BL/6 mice. (A) Percentage of CD27⁻CD11b⁻, CD27⁺CD11b⁻, CD27⁺CD11b⁺ and CD27⁻CD11b⁺ NK cells in NK1.1⁺ CD3⁻NK cell populations. Absolute numbers of NK cell subsets from the (B) spleen, (C) peripheral blood and (D) bone marrow. Freshly isolated peripheral blood cells from newly diagnosed patients with T-ALL or healthy controls. (E) Percentage of CD56^brightCD16^dim and (F) CD56^dim CD16^bright NK cells in the total NK cell population. (G) Absolute number of CD56^brightCD16^dim and CD56^dimCD16^bright NK cells. A-D: n=10 mice per group. E-G: n=8 healthy control group, and n=8 untreated T-ALL patients. The data are presented as the mean ± standard deviation; *P<0.05 and **P<0.01, as determined by one-way ANOVA or the unpaired Student's t-test. T-ALL, T-cell acute lymphoblastic leukemia; NK, natural killer; Notch1, neurogenic locus notch homolog protein 1; ns, not significant.