Figure 6.

Mutation diagram of HUWE1 in different cancer types across protein domains. The diagram presents the HUWE1 mutation sites and HUWE1 mutation frequencies. Mutation diagram circles are colored with respect to the corresponding mutation types. In case of different mutation types at a single position, color of the circle is determined with respect to the most frequent mutation type. The blue, yellow and magenta boxes on the gene represent different protein domains. The higher the value of the vertical axis, the higher the mutation rate. HUWE1, E3 ubiquitin-protein ligase; aa, amino acid.