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. 2019 Jul 5;18(3):2292–2303. doi: 10.3892/ol.2019.10579

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Copyright: © Su et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — CNAs of the HUWE1 gene in different cancer subtypes. The alteration frequency of HUWE1 was determined using the cBioPortal database. Cancer types containing >100 samples were selected and only alteration frequencies >20% are presented. The different colored circles represent different types of tumors. The alterations included amplifications (red), deletions (blue), multiple alterations (grey) or mutations (green). HUWE1, E3 ubiquitin-protein ligase; NEPC, neuroendocrine prostate cancer; Prostate, prostate cancer; Melanoma, Skin cutaneous melanoma cancer; Uterine, Uterine corpus endometrial carcinoma cancer; Lung squ, Lung squamous cell carcinoma cancer; Esophagus, Esophageal carcinoma cancer; Lung adeno, Lung adenocarcinoma cancer; Pan-lung, Pan-lung cancer; TCGA, The Cancer Genome Atlas; CNA, copy number alteration.