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. 2019 Jul 26;11:191. doi: 10.3389/fnagi.2019.00191

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Copyright © 2019 Koirala, Anwar, Ciolac, Glaser, Pintea, Deuschl, Muthuraman and Groppa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Fractional anisotropy (FA) differences. Axial and sagittal slices showing significant differences between (A) young and middle-aged healthy controls (HC_Y > HC_M), (B) middle-aged healthy controls and PD patients (HC_M > PD) and (C) young healthy controls and PD patients (HC_Y > PD). The slices show the threshold-free cluster enhancement (TFCE) thresholded results (p < 0.05, FWE corrected) superimposed on the FSL’s 1 mm MNI152 standard brain. The scale [1 – p-value] represents the significance of the clusters with yellow indicating higher and red indicating lower statistical significance. L and R denote the left and right hemisphere of the brain.