Table 3.
Allele and genotype frequencies of genetic polymorphisms among cases and controls and their main effects on stroke risk
| SNP | Cases | Percent | Controls | Percent | OR (95% CI) *a | P value b |
|---|---|---|---|---|---|---|
| rs1801282 | ||||||
| CC (reference) | 756 | 84.5 | 807 | 91.4 | 1.00 (reference) | |
| CG | 129 | 14.4 | 75 | 8.5 | 1.748 (1.209–2.581) | 0.003 |
| GG | 10 | 1.1 | 1 | 0.1 | 3.736 (0.430–32.436) | 0.232 |
| Dominant model CG + GG vs. CC | 1.844 (1.286–2.645) | 0.001 | ||||
| Recessive model CC + CG vs. GG | 0.298 (0.034–2.601) | 0.274 | ||||
| rs3856806 | ||||||
| CC (reference) | 515 | 57.5 | 587 | 66.5 | 1.00 (reference) | – |
| CT | 322 | 36.0 | 274 | 31.0 | 1.290 (1.011–1.647) | 0.041 |
| TT | 58 | 6.5 | 22 | 2.5 | 2.317 (1.274–4.214) | 0.006 |
| Dominant model CT + TT vs. CC | 1.366 (1.077–1.733) | 0.010 | ||||
| Recessive model CC + CT vs. TT | 0.424(0.239–0.751) | 0.003 |
ORs and 95% CIs were calculated based on multivariable logistic regression. Individuals with the heterozygous CG genotype for rs1801282 had a higher risk of ischemic stroke than individuals with the homozygous wild-type CC. The CG + GG genotype was associated with a significantly increased ischemic stroke risk. The CT and TT genotypes of rs3856806 were represented with increased frequency in the ischemic stroke patient group. The CT + TT genotype of rs3856806 was associated with ischemic stroke. *ORs and 95% CIs were calculated by logistic regression. a, bAdjusted OR (95% CI) and P value, adjusted for age, sex, body mass index, hypertension, diabetes mellitus, history of alcohol use, history of smoking, history of ischemic stroke, and hyperlipidemia. SNP: Single nucleotide polymorphism; OR: odds ratio; CI: confidence interval.