Table 5.
Stratified odds ratios for rs1801282 and rs3856806 with respect to the risk of ischemic stroke
| Stratum | SNPs | OR (95%CI) *a | P value b |
|---|---|---|---|
| Ischemic stroke | |||
| Stratified by rs1801282 | |||
| CG or GG | rs3856806 (CT or TT vs. CC) | 8.001 (2.559–25.016) | < 0.001 |
| CC | rs3856806 (CT or TT vs. CC) | 1.188 (0.928–1.522) | 0.171 |
| Stratified by rs3856806 | |||
| CT or TT | rs1801282 (CG or GG vs. CC) | 2.546 (1.639–3.954) | < 0.001 |
| CC | rs1801282 (CG or GG vs. CC) | 0.525 (0.245–1.123) | 0.097 |
ORs and 95% CIs were assessed based on multivariable logistic regression. The effect of the T risk allele at rs3856806 was stronger when rs1801282 had the G risk allele. A similar result was demonstrated for the effect of rs1801282 in relation to rs3856806. *ORs and 95% CIs were calculated by logistic regression. a, bAdjusted OR (95% CI) and P value, adjusted for age, sex, body mass index, hypertension, diabetes mellitus, history of alcohol use, history of smoking, history of ischemic stroke, and hyperlipidemia. SNP: Single nucleotide polymorphism; OR: odds ratio; CI: confidence interval.