Figure 1.

Polemic on the existence of adult neurogenesis in the human hippocampus.

Neurogenesis drops in children to negligible levels in adult humans (A, adapted from Sorrels et al., 2018). Endogenous neurogenesis persists in the hippocampus of adult humans, even in elderly people (B, adapted from Boldrini et al., 2018; C, adapted from Moreno-Jimènez et al., 2019). Methodological differences, including tissue overfixation, likely explains the discrepant results. DG: Dentate gyrus; DCX: doublecortin; NeuN: neuronal nuclear antigen.