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Aflatoxin B1 (AFB1) induced proliferation foci in liver after repeated-dose treatment. 75 μg/kg AFB1 treatment induced formation of proliferation focus after 4-week (A) and 5-week (B) treatment (arrow). The altered foci were characteristic of clear cytoplasm and many cells have a centrally located nucleus (clear cell foci). Bars represent 50 μm.
