Table 6.—
Liver GST-P+ cells and foci induced by repeated-dose treatment with AFB1.
| Time (week) | ||||||
|---|---|---|---|---|---|---|
| GST-P+ | Dose (μg/kg) | 1 | 2 | 3 | 4 | 5 |
| Cells | 5 | — | — | 14.99 ± 12.55 (3/5) | 18.83 ± 10.28 (2/5) | 16.74 ± 13.20 (2/5) |
| 10 | — | 7.66 ± 0.99 (5/5) | 12.79 ± 11.11 (4/5) | 37.88 ± 17.78 (5/5) | 61.35 ± 51.88 (5/5) | |
| 25 | 20.97 ± 7.46 (5/5) | 19.42 ± 5.98 (5/5) | 30.02 ± 14.59 (5/5) | 56.60 ± 16.28 (5/5) | 95.35 ± 34.91 (5/5) | |
| 75 | 21.47 ± 11.62 (5/5) | 63.36 ± 11.57 (5/5) | 245.42 ± 92.78 (5/5) | 203.65 ± 82.77 (5/5) | 259.80 ± 41.19 (5/5) | |
| Foci | 5 | — | — | — | — | — |
| 10 | — | — | — | — | 1.49 ± 2.57 (2/5) | |
| 25 | — | — | 1.36 ± 1.22 (3/5) | 1.12 ± 1.94 (2/5) | 9.24 ± 12.78 (3/5) | |
| 75 | — | — | 3.01 ± 2.87 (3/5) | 39.09 ± 4.67 (5/5) | 75.99 ± 23.58 (5/5) | |
Note: GST-P+, placental form glutathione S transferase.
Data are mean values from 5 liver sections, each from an individual rat (No./cm2).
—, not found. Data in parentheses are (no. of animals affected/no. of animals examined).