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. 2019 Aug;60(10):3320–3331. doi: 10.1167/iovs.18-25647

Figure 6.

Figure 6

Treatment with VP1-001 significantly increases protein solubility in lenses of cryAB(R120G) mutant mice, but ent-VP1-001 is inactive. Homogenized tissue from cryAB(R120G) heterozygous mice treated with vehicle, VP1-001 (A), or ent-VP1-001 (C) were separated by GPC and measured by RI to reveal peaks for α--, β-, and γ-crystallins. Alternatively, samples were measured for RALS to study the molecular mass of soluble α-crystallin (B, D). Treatment with VP1-001 (A), but not ent-VP1-001 (C), increased the amount of soluble lens protein compared with vehicle. In all chromatography traces, the treatments were compared with vehicles taken from the contralateral eye of the same mouse.