Table VI.
Mean Detection Times and Ranges of THC and THCCOOH in Oral Fluid by THC Dose (10, 25 mg) and Inhalation Method (Smoked and Vaporized)
| Dose (mg) | THC ELISA (cutoff = 4 ng/mL) | THCCOOH ELISA (cutoff = 0.05 ng/mL) | THC LC–MS-MS (LOQ = 0.5 mg/mL) | THCCOOH LC–MS-MS (LOQ = 0.02 ng/mL) |
|---|---|---|---|---|
| Smoked: Detection time (h) to first positive | ||||
| 10 | 0.19 (0.17–0.5) | 0.17 (0.17–0.17) | 0.19 (0.17–0.5) | 3.25 (0.5–6.0) |
| 25 | 0.17 (0.17–0.17) | 0.17 (0.17–0.17) | 0.17 (0.17–0.17) | 6.0 (6.0–6.0) |
| Smoked: Detection time (h) to last positive | ||||
| 10 | 3.16 (0.17–8.0) | 1.87 (0.17–6.0) | 5.89 (2.0–8.0) | 6.5 (5.0–8.0) |
| 25 | 5.76 (1.0–8.0) | 4.35 (0.5–8) | 7.06 (4.0–8.0) | 7.3 (6.0–8.0) |
| Vaporized: Detection time (h) to first positive | ||||
| 10 | 0.17 (0.17–0.17) | 0.17 (0.17–0.17) | 0.17 (0.17–0.17) | 1.67 (0.5–3.0) |
| 25 | 0.17 (0.17–0.17) | 0.17 (0.17–0.17) | 0.17 (0.17–0.17) | 3.25 (0.5–6.0) |
| Vaporized: Detection time (h) to last positive | ||||
| 10 | 2.72 (0.17–8.0) | 1.61 (0.17–8.0) | 5.15 (1.0–8.0) | 3.17 (1.5–5.0) |
| 25 | 4.23 (0.5–8.0) | 3.72 (0.17–8.0) | 7.06 (4.0–8.0) | 6.0 (4.0–8.0) |
Note: Sessions in which participants could not produce a saliva sample immediately after self-administration were not included in time to first detection analyses (Table II).