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. 2019 Jul 26;10:1725. doi: 10.3389/fimmu.2019.01725

Figure 3.

Figure 3

Induction of TNF-α by the transgenic strain improve survival and fungal containment in comparison with the WT strain. BALB/c mice were infected with an intratracheal inoculation of 104 cells of H99-α or WT C. neoformans strain H99. Fungal burden from lungs (A) and brains (B) were quantified at different time points. (C) Mice survival was evaluated. N = 10 mice per group. (D) H99-α infected mice showed comparable fungal burden in both lungs and brains with H99 at time of death. BALB/c mice were infected with an intratracheal inoculation of 104 cells of H99-α or WT C. neoformans strain H99. Fungal burden from lungs and brains were quantified when mice dead (weight loss ≥ 20%). Note that the number on the graph (A) indicates in the initial inoculation dose of fungal organisms. The numbers on the graph (B) indicate the number of mice which are detected with fungal dissemination out of the group size (Results represent mean ± SEM; *P < 0.05; ***P < 0.001; ****P < 0.0001).