Figure 4.

Production of TNF-α by the transgenic strain does not induce excessive inflammatory response or severe pathology in the infected lungs. Lungs from mice infected with H99-α or H99 were harvested at 14 dpi followed by Haemotoxylin & Eosin staining. The photographs were taken at ×20 (A,B) and ×40 objective power (C,D). Note that H99-α-infected lungs showed different inflammatory features such as improved containment of the yeast, more condensed leukocytes infiltration around the infection site and less pronounced granulocyte responses than H99-infected lungs.