Table 3. Top 15 GO enrichment terms of differentially expressed genes associated with hepatitis B-related hepatocellular carcinoma.

Expression	Category	Term	Count	%	P value
upregulated	BP	GO:0007049∼cell cycle	43	38.39286	7.63E-28
	BP	GO:0000279∼M phase	32	28.57143	2.48E-27
	BP	GO:0022403∼cell cycle phase	33	29.46429	1.59E-25
	BP	GO:0007067∼mitosis	27	24.10714	2.03E-25
	BP	GO:0000280∼nuclear division	27	24.10714	2.03E-25
	CC	GO:0005819∼ mitotic spindle	21	18.75	1.43E-21
	CC	GO:0015630∼microtubule cytoskeleton	24	21.42857	2.84E-13
	CC	GO:0044430∼cytoskeletal part	25	22.32143	3.19E-09
	CC	GO:0005856∼cytoskeleton	28	25	5.91E-08
	CC	GO:0000922∼spindle pole	7	6.25	6.75E-08
	MF	GO:0005524∼ATP binding	24	21.42857	3.45E-05
	MF	GO:0032559∼adenyl ribonucleotide binding	24	21.42857	4.27E-05
	MF	GO:0030554∼adenyl nucleotide binding	24	21.42857	9.64E-05
	MF	GO:0001883∼purine nucleoside binding	24	21.42857	1.22E-04
	MF	GO:0001882∼nucleoside binding	24	21.42857	1.35E-04
downregulated	BP	GO:0055114∼oxidation reduction	36	16.66667	7.03E-14
	BP	GO:0045087∼innate immune response	15	6.944444	1.67E-09
	BP	GO:0006956∼complement activation	10	4.62963	1.78E-09
	BP	GO:0009611∼response to wounding	27	12.5	1.84E-09
	BP	GO:0002541∼activation of plasma proteins involved in acute inflammatory response	10	4.62963	2.23E-09
	CC	GO:0005576∼extracellular region	83	38.42593	2.05E-21
	CC	GO:0044421∼extracellular region part	50	23.14815	9.40E-16
	CC	GO:0005615∼extracellular space	41	18.98148	8.87E-15
	CC	GO:0005792∼microsome	17	7.87037	2.50E-07
	CC	GO:0042598∼vesicular fraction	17	7.87037	3.70E-07
	MF	GO:0009055∼electron carrier activity	23	10.64815	1.17E-13
	MF	GO:0019825∼oxygen binding	12	5.555556	5.61E-12
	MF	GO:0005506∼iron ion binding	22	10.18519	5.88E-10
	MF	GO:0020037∼heme binding	14	6.481481	6.05E-09
	MF	GO:0046906∼tetrapyrrole binding	14	6.481481	1.33E-08

Notes.

BP

biological process

CC

cellular component

MF

molecular function

GO

gene ontology